四氯合钯(II)喹诺酮配合物的合成及与DNA的作用和抗增殖活性

在酸性条件下, 分别合成了四氯合钯(II)离子与2种喹诺酮(诺氟沙星, NFLX＝C16H18N3O3F; 环丙沙星, CPLX＝C17H18N3O3F)离子形成的配合物(NFLXH)2[PdCl4]•2H2O (1)和(CPLXH)2[PdCl4]•2H2O (2). 用元素分析、IR、UV以及摩尔电导测定等方法对其进行了表征. 配合物1的晶体结构经X射线单晶衍射确定, 结构参数: 三斜晶系, P-1空间群, a＝0.84561(17) nm, b＝0.94191(19) nm, c＝1.2832(3) nm; α＝111.26(3)°, β＝97.23(3)°, g＝96.38(3)°, V＝0.9312(4) nm3, Z＝1, 最后吻合因子R＝0.040, wR＝0.088. 利用紫外光谱法、荧光光谱法对配合物与小牛胸腺DNA (ct-DNA)的作用进行了研究, 研究表明, 配合物对DNA的作用模式为插入作用, 与DNA的结合常数Kb分别为: Kb(1)＝2.06×104, Kb(2)＝2.43×104. 其后测试了配合物对体外肿瘤细胞的抗增殖活性. 经采用四甲基偶氮唑蓝分析法(MTT法)测试后发现配合物1和2对人肺腺癌A549细胞、人原髓细胞白血病HL-60细胞的增殖抑制作用显著强于相应的喹诺酮分子本身, 其中配合物2对人肺腺癌A549细胞增殖有明显的抑制作用, 抑制率可高达(95.4±3.7)%, 半数抑制浓度(IC50, 72 h)为(124.5±10.3) μmol•L－1.     

固相萃取毛细管气相色谱法测定卷烟滤嘴中7种挥发性羰基化合物

建立了SPE-GC测定卷烟滤嘴中7种挥发性羰基化合物,采用2,4-二硝基苯肼酸性溶液捕集滤嘴中挥发性羰基化合物,捕集液经Waters C18固相萃取小柱纯化和富集,用GC检测.7种羰基化合物检出限分别为0.02、 0.07、 0.04、 0.03、 0.03、 0.02、 0.03 μg/mL;回收率范围在92.0%～99.5%之间;相对标准偏差均小于5%.方法应用于国内5种烤烟型卷烟滤嘴的分析,得到理想结果.     

多壁碳纳米管修饰碳黑微电极同时测定多巴胺和抗坏血酸

制备了多壁碳纳米管修饰碳黑微电极,研究了多巴胺(DA)和抗坏血酸(AA)在该修饰电极上的电化学行为.实验表明,在pH 7.0的PBS缓冲溶液中,该修饰电极对DA和从均具有显著的催化氧化作用,AA与DA的氧化电位分别为30 mV和280 mV(vs.SCE).利用二次导数线性扫描伏安法测定,DA与AA的线性范围分别为6.0×10-9～2.0×10-4 mol/L和2.0×10-7～1.0×10-3mol/L,检出限为2.0×10-9mol/L 和1.0×10-7mol/L.方法已用于人工合成样品的分析.     

Attractor for lattice system of dissipative Zakharov equation

We consider the asymptotic behavior of solutions of an infinite lattice dynamical system of dissipative Zakharov equation. By introducing new weight inner product and norm in the space and establishing uniform estimate on ＂Tail End＂ of solutions, we overcome some difficulties caused by the lack of Sobolev compact embedding under infinite lattice system, and prove the existence of the global attractor; then by using element decomposition and the covering property of a polyhedron in the finite-dimensional space, we obtain an upper bound for the Kolmogorov ε-entropy of the global attractor; finally, we present the upper semicontinuity of the global attractor.     

Near-infrared Responsive Photoelectrochemical Biosensors

Near-infrared (NIR) light-driven photoelectrochemical (PEC) sensing is a highly promising analytical technique, especially for in situ bioanalysis, due to the deep penetration capability and minimal invasiveness of NIR light. In this mini review, we provide a brief overview of recently developed NIR PEC sensors, focusing on NIR light-responsive materials and the representative applications of this type of PEC sensor. Future perspectives for NIR PEC sensors are also described.     

The negative electromagnetic attractive forces arising from kinetic energy of conduction electrons in double-layer metallic nanowire arrays

The coupled-nanowire plasmatic resonances and very strong negative electromagnetic force between the double-layer metallic nanowire arrays is investigated theoretically. The negative electromagnetic force indicates attractive interaction between the metallic nanowires with the air-gap cavity local resonance effect. Plasmon resonances lead to extremely large localized ?eld, thereby resulting in large mutual coupling forces between the double-layer metallic nanowire arrays. The light coupling into metallic microcavity can stimulate collective electron oscillations of plasmatic resonance, and cause the contraction of the negative pressure in metallic cavity wall. The electromagnetic field of the plasmatic resonance mode is mainly localized inside the air-gap region between the two wires.     

Comparison of modeling calculations with experimental results for direct current glow discharge optical emission spectrometry

A comparison is made between numerical modeling and experimental results for the electrical characteristics, the erosion rates and the optical emission intensities of various argon and copper lines in a direct current glow discharge, to verify the model calculations and to illustrate some features and limitations of the model. In order to reach good agreement with the current–voltage characteristics, the gas temperature, which was treated as an adjustable parameter, was assumed to increase slightly as a function of voltage and pressure. This assumption is in accordance with theoretical predictions and experimental observations in the literature. The erosion rates and optical emission intensities, calculated as a function of voltage and pressure, were also found to be in reasonable agreement with the experimental data. However, it appeared that still better agreement with the measured data could be reached when the gas temperature was assumed to be constant as a function of voltage. This illustrates that the effect of voltage cannot yet be completely correctly predicted for both the electrical current and the erosion rates and optical emission intensities at the same time, and that, therefore, the glow discharge behavior is not yet perfectly described in the model. This is not unexpected in view of the complexity of the model calculations and the uncertainties of some input data. However, in general, the agreement between model results and experimental data is satisfactory, so that it can be concluded that the model gives already a realistic picture of the direct current glow discharge.     

激光对分子振动态的控制与量子Fredkin逻辑门

基于激光相干合成分子的局域模振动态,提出利用激光对分子振动态的控制实现量子Fredkin逻辑门的功能,并对方案的特点及可行性进行分析.     

An immersed boundary–lattice Boltzmann approach to study the dynamics of elastic membranes in viscous shear flows

A combined immersed boundary–lattice Boltzmann approach is used to simulate the dynamics of elastic membrane immersed in a viscous incompressible flow. The lattice Boltzmann method is utilized to solve the flow field on a regular Eulerian grid, while the immersed boundary method is employed to incorporate the fluid–membrane interaction with a Lagrangian representation of the deformable immersed boundary. The distinct feature of the method used here is to employ the combination of simple Peskin's IBM and standard LBM. In order to obtain more accurate and truthful solutions, however, a non-uniform distribution of Lagrangian points and a modified Dirac delta function are used. Two test cases are presented. In the first case, we consider a vesicle suspended in a simple shear flow commonly known as tank-treading motion. The computed results were compared with experiments, which showed reasonably good agreement. For the second test case, we consider individual healthy (soft) and sick (stiff) RBCs suspended in a shear flow. The simulation results demonstrated that elastic deformation plays an important role in overall RBC motions characterized as tank-treading and tumbling motions, in which the natural state of the elastic membrane is an essential consideration. In addition, the results confirm that the combination of the immersed boundary and lattice Boltzmann methods permits the simulation of the complex biological phenomena.